课题组简介：

课题组现有教师10人，教授2人，副教授5人，博士后2人及硕士1人。在读博士研究生2人，硕士研究生39人。

本课题组以昆虫资源和微生物等为研究对象或者材料，采用分子生物学、细胞生物学、蛋白组学、RNAi和基因编辑等技术手段，研究昆虫发育、免疫和繁殖的调控分子机制，并对微生物和资源昆虫进行开发应用，挖掘活性物质和功能性蛋白，致力于害虫生物防治和经济昆虫功能性产品的开发。在相关研究领域形成了课题组明显的特色和优势，已取得了一些重要成果，近5年在学科TOP期刊Journal of Agricultural and Food Chemistry、Entomologia Generalis、Journal of Pest Science、Pesticide Biochemistry and Physiology、Science of the Total Environment、Environmental pollution、Frontiers in Immunology、Insect Science、Journal of the Science of Food and Agriculture、International Journal of Biological Macromolecules、LWT-Food Science and Technology和Food Chemistry等国际著名期刊杂志发表科技论文40余篇。

课题组先后承担国家自然科学基金面上项目和青年项目、国家科技支撑计划子课题、浙江省自然科学基金一般项目和青年项目、杭州市农业与社会发展科研重点项目等50余项课题；获省级自然科学奖2项。课题组以科研项目为依托，以培养学生综合素养为导向，共培养浙江省优秀毕业研究生4人，浙江省优秀本科毕业生10余人。指导本科生获得第十五届“挑战杯”中国银行全国大学生课外学术科技作品竞赛一等奖1项、全国大学生生命科学竞赛国家一等奖10余项；累计指导学生获各类学科竞赛省一等及以上奖项30多项。

课题组照片：

课题组负责人：唐斌（教授）

课题组成员

教师：王世贵（教授）、周婷（副教授）、朱芹（副教授）、白雪莲（副教授）、许明峰（副教授）、石陆娥（副教授）、周敏（硕士）、李燕（博士后）、王杰（博士后）

学生：博士生（万思景、陶少敏）；硕士生（管丽雯、徐佳莹、李柒梅、葛雨欣、胡尚容、韩烨、祝阳、罗炎琳、杨帆、郝兴亚、倪想想、刘绮伟、陈呈呈、任余贵、潘靖怡、钟樊、周彦飞、张心雨、张雨丫、黄志伟、黎珊珊、潘慧婕、张祎程、何佳琳、周嘉千、滕敏、王思翟、叶昕培、胡燕钰、胡章洁、沈慧扬、姜中宝、夏文清、张雨、梁琳茜、周鑫惠，孙章妍，刘堉萍、张哲一）

主要研究方向

1. 资源昆虫的规模化生产及开发应用

2. 昆虫对重金属及农残污染胁迫的响应机制

3. 昆虫生理生态及害虫生物防治

4. 昆虫海藻糖代谢重要基因功能及害虫控制机制

5. 天然产物中活性成分鉴定及应用

6. 蛋白资源食品化创新加工与利用

7. 微生物资源利用与开发

8. 农产品贮藏保鲜及品质调控

代表性成果：

1.       Zhang C, Shen JY, Lan RY, Xu JY, Ma TT, Tang B, Wang SG^*. Target of rapamycin (TOR) is necessary for the blood digestion and reproduction of Aedes albopictus. Journal of Pest Science, 2025, Doi: 10.1007/s10340-024-01862-2.

2.       Xu JY, Tang Y, Jin Y, Ma TT, Zhang C, Lou JN, Tang B, Wang SG^*. Knockdown of FAS2 Impairs Fecundity by Inhibiting Lipid Accumulation and Increasing Glycogen Storage in Locusta migratoria. Insects, 2025, 16: 120.

3.       Xu J, Zhang Y, Hu Z, Du Z, Xie B, Hu C, Liu J, Zhu Q^*. Inhibition of Glyoxal-Induced Protein Glycation by Quercetin in a Simulated Dairy System. Journal of Food Science, 2025, 90(5), e70252.

4.       Liu Y, Gong Y, Pan H, Guo Z, Tang Z, Zhang Y, Han J, Liu J, Xie C, Xu J, Zhu Q^*. Impacts of kaempferol on α-dicarbonyls mediated protein modification during simulated heat-treatment of β-lactoglobulin. Food Chemistry: X, 2025, 103247.

5.       Xu MF, Li RX, Li MT, Duan CY, Wei YY, Ni XX, Wang X, Fu SD, Yu RR. Tenebrio molitor powder enhances gelation properties of Penaeus vannamei myofibrillar protein: Mechanistic insights into structural optimization and digestibility. Food Chemistry, 2025, 490: 145065.

6.       Zhou T, Yang YJ, Wang F, Liang LQ, Zhang ZQ, Dong HR, Jiang ZC, Zhang PC*, Lai TF*. Transcriptomic Profiling of mRNA and lncRNA During the Developmental Transition from Spores to Mycelia in Penicillium digitatum, Microorganisms, 2025, 13, 2879.

7.       Hu SR, Wan SJ, Zhang XY, Wang XZ, Guan LW, Ge YX, Li Y, Luo JL^*, Tang B^*. Structure, production and application of spider silks. International Journal of Biological Macromolecules, 2025, 309: 142939.

8.       Wang XZ, Wan SJ, He BE, Wang SL, Wang TW, Yu LH, Wang SG, Wang HZ, Tang B^*, Lu JJ^*. Physalis floridana suppressed the expression of trehalase gene HvTREs in Henosepilachna vigintioctopunctata (Coleoptera: Coccinellidae) for defense against herbivorous insects. Journal of Pest Science, 2025, 98: 1101-1116

9.       Liu YK^†, Zhu Y^†, Wan SJ, Wang XZ, Guan LW, Xu CD, Xie BH, Wang SG, Sun SS^*, Tang B^*. Trehalase regulates ovarian maturation and egg hatchability of Nilaparvata lugens (Stål). Journal of Pest Science, 2025, Doi: org/10.1007/s10340-025-01903-4

10.   Ye XP , Hu YY , ChenYX , Tang ZX , Jiang ZB , Fu Y , Wang ZX , Pi EX , Bian GF, Shi LE^*. Flavonoids from the genus Polygonatum: biological activities and biosynthesis mechanism. Frontiers in Nutrition, 2025, 12: 1574182

11.   Tang ZX, Ye XP, Jiang ZB, ChenYX, Shen HY , Hu YY, Shi LE^*. Extraction and processing of Polygonatum flavonoids: a review. Frontiers in Sustainable Food Systems, 2025, 9: 1569034

12.   Ma TT, Ding YJ, Xu FJ, Zhang C, Zhou M, Tang Y, Chen YR, Wen YT, Chen RF, Tang B, Wang SG. Effects of acute and chronic chromium stress on the expression of heat shock protein genes and activities of antioxidant enzymes in larvae of Orthetrum albistylum. Environmental pollution, 2024, 340: 122712.

13.   Tang B, Han Y, Mao QX, Fu HY, Luo YJ, Hua LYH, Liu BS, Hu G, Wang SG, Desneux N, Duan HX, Wu Y. Regulation of three novel pepper thiothiazolidinones on the fecundity of Spodoptera frugiperda. Pesticide Biochemistry and Physiology. 2024, 204: 106033.

14.   Li Y, Wang SS, Si HR, Wan SJ, Li GY, Shu YH, Dai XY, Wang RJ, Wang SG, Zhai YF, Li C, Tang B. Responses of aphid and ladybird to lead transfer through soil and broad beans. Entomologia Generalis, 2024, 44(3): 621-631.

15.   Tang B, Hu SR, Luo YJ, Shi DM, Liu XY, Zhong F, Jiang XY, Hu G, Li C, Duan HX, Wu Y. The impact of three thiazolidinone compounds with piperine skeletons on trehalase activity and development of Spodoptera frugiperda larvae. Journal of Agricultural and Food Chemistry, 2024, 72(15):8423-8433.

16.   Xu MF, Ni XX, Liu QW, Chen CC, Deng XH, Wang X, Yu RR. Ultra-high pressure improved gelation and digestive properties of Tai Lake whitebait myofibrillar protein. Food Chemistry: X, 2024, 21: 101061.

17.   Yao WH, Hao XY, Hu Z, Lian ZH, Cao Y, Liu R, Niu XY, Xu J, Zhu Q. Mitigation of malondialdehyde-induced protein lipoxidation by epicatechin in whey protein isolate. Food chemistry, 2024, 456: 139954.

18.   Zhou T, Pan JJ, Wang JJ, Yu QR, Zhang PC, Lai TF. Inhibitory Properties of Cinnamon Bark Oil against Postharvest Pathogen Penicillium digitatum in Vitro. Journal of Fungi, 2024, 10(4): 249.

19.   Zhou H, Hu YY, Tang ZX, Jiang ZB, Shen HY,Ye XP, Huang XY,Wang X, ZhouT,Bai XL,Zhu Q, Shi LE^*. Calcium transport and enrichment in the microorganisms: a review. Foods, 2024, 13(22): 3612

20.   Huang XY, Ye XP, Hu YY,Tang ZX,Zhang T, Zhou H, Zhou T, Bai XL, Pi EX , Xie BH, Shi LE^*. Exopolysaccharides of Paenibacillus polymyxa: a review. International Journal of Biological Macromolecules, 2024, 261: 129663.

21.   Tang Y, Hu YW, Wang SH, Zhou M, Ding YJ, Cai SQ, Tang B, Wang SG. RNAi-mediated CrebA silencing inhibits reproduction and immunity in Locusta migratoria manilensis. Developmental and Comparative Immunology, 2023, 145: 104711.

22.   Zhang C, Ding YJ, Zhou M, Tang Y, Chen RF, Chen YR, Wen YT, Wang SG. RNAi-mediated CHS-2 silencing affects the synthesis of chitin and the formation of the peritrophic membrane in the midgut of Aedes albopictus larvae. Parasites & Vectors, 2023, 16: 1- 13.

23.   Bai XL, Sheng Y, Tang ZX, Pan JY, Wang SG, Tang B, Zhou T, Shi LE, Zhang HW. Polyketides as secondary metabolites from the genus Aspergillus, Journal of Fungi, 2023, 9(2): 261.

24.   Xu MJ, Huang ZW, Zhu WJ, Liu YY, Bai XL, Zhang HW. Fusarium-derived secondary metabolites with antimicrobial effects, Molecules, 2023, 28(8): 3424.

25.   Lian ZH, Han JH, Cao Y, Yao WH, Niu XY, Xu MF, Xu J, Zhu Q. Epicatechin inhibited lipid oxidation and protein lipoxidation in a fish oil-fortified dairy mimicking system. Foods, 2023, 12, 1559.

26.   Lai TF, Yu QR, Pan JJ, Wang JJ, Tang ZX, Bai XL, Shi LE, Zhou T. The identification and comparative analysis of non-coding RNAs in spores and mycelia of Penicillium expansum. Journal of Fungi, 2023, 9(10): 999.

27.   Tang ZX, Shi LE^*,Jiang ZB, Bai XL, Ying RF. Calcium enrichment in edible mushrooms: a review, Journal of Fungi, 2023, 9(3): 338.

28.   Hu YW, Wang SH, Tang Y, Xie GQ, Ding YJ, Xu QY, Tang B, Zhang L, Wang SG. Suppression of yolk formation, oviposition and egg quality of locust (Locusta migratoria manilensis) infected byParanosema locustae. Frontiers in Immunology, 2022, 13:848267.

29.   Luo YJ, Chen Y, Wang ST, Yang YY, Xu HX, Wang XJ, Qu C, Wu Y, Li C, Tang B, Wang S. Validamycin affects the development and chitin metabolism in Spodoptera frugiperda by inhibiting trehalase activity. Entomologia Generalis, 2022, 42(6): 931-939

30.   Li Y, Wang SS, Wang S, Wang SG, Tang B, Liu F. Involvement of glucose transporter 4 in ovarian development and reproductive maturation of Harmonia axyridis (Coleoptera: Coccinellidae). Insect Science, 2022, 29(3):691-703.

31.   Zhou T, Li R, Yu QR, Wang JJ, Pan JJ, Lai TF. Proteomic Changes in Response to Colorless nonripening Mutation during Tomato Fruit Ripening. Plants, 2022, 11(24): 3570.    

32.   Bai XL, Liu Y, Wang H, Zhang HW. Natural products from the marine sponge subgenus Reniera, Molecules, 2021, 26(4): 1079.

33.   Xu MF, Shen CJ, Zhu Q, Xu YS, Xue CF, Zhu BW, Hu JN. Comparative metabolomic and transcriptomic analyses revealed the differential accumulation of secondary metabolites during the ripening process of acerola cherry (Malpighia emarginata) fruit. Journal of the Science of Food and Agriculture, 2021,102(4): 1488-1497.

34.   Xu MF, Lian ZH, Chen XQ, Yao X, Lu CR, Niu XY, Xu MJ, Zhu Q. Effects of resveratrol on lipid and protein co-oxidation in fish oil-enriched whey protein isolate emulsions, Food Chemistry, 2021, 365: 130525.

35.   Lai TF, Sun YY, Liu YY, Li R, Chen YZ, Zhou T. Cinnamon Oil Inhibits Penicillium expansum Growth by Disturbing the Carbohydrate Metabolic Process. Journal of Fungi, 2021, 7: 0-123.

36.   Xu MF, Sun MF, Lu CR, Han YT, Yao X, Niu XY, Xu MJ, Zhu Q. Influence of epicatechin on oxidation-induced physicochemical and digestibility changes in porcine myofibrillar proteins during refrigerated storage. Journal of the Science of Food and Agriculture, 2021, 101, 746-753.

37.   Cen QW, Wang ZY, Tang ZX, Zhang Y, Chen HJ, Wu DT , Song XY, Chen T, Xue DW，Xu MF , Bai XL, Zhou T，Shi LE^* . Initial purification of antimicrobial fermentation compounds from Paecilomyces cicadae and its antimicrobial mechanism, LWT-Food Science and Technology, 2021, 148: 111785.